WELCOME! The Castillo Laboratory for Mechanobiology & Regenerative Medicine studies interactions between mechanobiological cues and musculoskeletal systems with the long-term goal of developing novel biophysical, pharmaceutical, and stem cell-based interventions to improve musculoskeletal health. We use in vivo and in vitro approaches including engineering tools and analyses, state-of-the-art cell and molecular biology techniques, and translational experimentation to identify, characterize, and manipulate key mechanisms by which multipotent stem cells and lineage-determined cells sense and respond to mechanical and biochemical stimuli. Specific tools include genetically engineered model organisms, mechanical force application, biomechanical testing, stem cell transplantation, engineered microfluidic devices, and computational analyses. Our research facilities are located at the Veterans Affairs Medical Center, Manhattan Campus, and at the NYU Hospital for Joint Diseases. We are grateful for funding from the Department of Veterans Affairs, the AO Foundation, the NYU Center for Skeletal and Craniofacial Biology, and the NYU Clinical and Translational Science Institute.